2 · Matrix, regenerative agents & supportive devices
Collagen shields
Review — modulators of corneal healing › 2 · Matrix, regenerative agents & supportive devices › Collagen shields
Collagen shields
Cross-linked porcine/bovine collagen disc, dissolving in 12/24/72 h · largely obsolete
Oxford IV–V
Weak / Investigational
Past
Mechanism of actionDual function: mechanical bandage plus a dissolving collagen scaffold (migration support), and a drug-eluting reservoir (antibiotics/corticosteroids) that increases corneal contact time. Biodegradable (no removal required).
Indications (historical)Post-surgical healing (post-keratoplasty, RK/PRK era), post-abrasion, prolonged drug-delivery vehicle.
Route & dosagePlaced on the cornea (rehydrated), left in place until dissolution (12/24/72 h); can be pre-soaked in medication.
Level of evidenceOxford IV–V · Scale: Weak / Investigational — never demonstrated superiority over soft lenses; blurred vision, discomfort. Superseded.
| FDA | Approved in the late 1980s–90s; now virtually withdrawn from the market. |
|---|---|
| EU MA | Historically CE-marked; current supply is virtually nonexistent. |
| France / USA / Asia | Replaced by silicone hydrogel + amniotic membrane; residual availability. Concept revived in research (nanoparticle/drug-eluting systems). |
Key studies: Willoughby et al., Surv Ophthalmol 2002 (review) — PMID 11918897 ; Poland & Kaufman (drug elution, 1988) — PMID 3183929.