Ocular toxicity of ADCs — molecule fact sheets

The eye marker places the antigen within the healthy eye. Red: expressed in the cornea itself — epithelium, limbus, stroma or endothelium; an on-target component is possible, compartment depth does not rule it out. Amber: expressed outside the cornea only — conjunctiva, lacrimal apparatus, uvea. Green: looked for and not found; toxicity there is necessarily off-target. Grey: never looked for on cornea or conjunctiva — absence of data, not absence of expression. The label that follows gives the level of evidence: human staining, cell-lineage inference, or animal data. Each sheet also carries a three-level evidence note with its reference: human expression — shown in human ocular tissue; animal expression only — shown in animals and not transposed to humans; no expression found — antigen never stained in the human eye, or looked for and absent. Expression is necessary but not sufficient: the ADC must also reach the compartment. Revised 23 August 2026.

Type the first letters of a molecule, brand, target or payload. Molecules are grouped by cytotoxic payload, the axis that best predicts ocular risk.

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Disclaimer. This tool summarises published data and the author's clinical experience. It does not replace current product information, which prevails in case of divergence, nor multidisciplinary clinical judgement. Numerical incidences derive from the chapter Ocular toxicity of antibody-drug conjugates and from the review published in Prog Retin Eye Res 2024;103:101302. Qualitative statements from pharmacovigilance are flagged as such. Regulatory status verified August 2026.